… and progesterone analogue-inducible systems. Some of the challenges still remaining in
all regulatable gene expression systems include leaky gene expression in the off state, which …

… of hsp gene regulation, not only … gene expression than chemicals. As shown by multiple
studies that assessed heat induction of endogenous hsp genes or of transduced reporter genes …

… limited or no therapeutic options. Below, we will review the importance and challenges of
the future implementation of regulatable gene expression systems in gene therapy clinical trials…

… of therapeutic genes to targeted mammalian cells as well as regulatable gene expression.
Advances in gene therapy have mainly focused on the development of viral …

… -regulated gene expression systems are available for controlling target gene transcription
through the use of small-molecule inducing compounds. While the utility of such systems has …

… To be used in human gene therapy, a pharmacologically regulated system should fulfill …
be exploited to generate a series of gene regulation systems. The generation of an additional …

… for the delivery of regulated transgene expression and the impact of conditional … A panoply
of different inducible mammalian cell-compatible gene regulation systems was developed in …

… in gene regulation has been at the transcriptional level and as such gene regulation systems
… The tetracycline regulated gene expression system developed by Gossen and Bujard [2] is …

… Many different regulated gene expression systems … regulation of genes by gene therapy
. Two are active at the transcriptional level and target either transgenic or endogenous genes. …

… regulatable systems for controlled gene expression and strategies and potential problems for
optimizing transgene expression… of gene function, stem cell gene transfer, gene therapy for …