Autophagy is an intracellular protein-degradation process that is conserved across
eukaryotes including yeast and humans. Under nutrient starvation conditions, intracellular
proteins are transported to lysosomes and vacuoles via membranous structures known as
autophagosomes, and are degraded. The various steps of autophagy are regulated by the
target of rapamycin complex 1 (TORC1/mTORC1). In this review, a history of this regulation
and recent advances in such regulation both in yeast and mammals will be discussed …