Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate …
PJ Randle, EA Newsholme, PB Garland - Biochemical Journal, 1964 - ncbi.nlm.nih.gov
METHODS Muscle extracd8. For assay of glucose or pentose heart muscle was extracted
with boiling water as described by Battaglia & Randle (1960). Glycogen synthesis. This was
assayed by the change in glycogen concentration during perfusion of rat heart or incubation
of rat hemidiaphragms. The initial glycogen was measured in heart muscle on separate
hearts washed through with 10-15 ml. of medium. With hemidiaphragms one member of
eachpair was used for assayof the initial glycogen concentration and the other incubated …
with boiling water as described by Battaglia & Randle (1960). Glycogen synthesis. This was
assayed by the change in glycogen concentration during perfusion of rat heart or incubation
of rat hemidiaphragms. The initial glycogen was measured in heart muscle on separate
hearts washed through with 10-15 ml. of medium. With hemidiaphragms one member of
eachpair was used for assayof the initial glycogen concentration and the other incubated …
Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy …
EA Newsholme, PJ Randle - Biochemical Journal, 1964 - ncbi.nlm.nih.gov
Newsholme & Randle (1961) found that the con-centrations of glucose 6-phosphate and
fructose 6-phosphate were decreased and that of fructose 1, 6-diphosphate was increased
by anoxia in perfused isolated rat heart. Starvation of the rat, on the other hand, increased
the concentration of hexose monophosphates and diminished that of the diphosphate.
Regen, Davis & Morgan (1961) have observed in perfused hearts from alloxan-diabetic rats
changes in hexose phosphate concentrations similar to those that we have seen in …
fructose 6-phosphate were decreased and that of fructose 1, 6-diphosphate was increased
by anoxia in perfused isolated rat heart. Starvation of the rat, on the other hand, increased
the concentration of hexose monophosphates and diminished that of the diphosphate.
Regen, Davis & Morgan (1961) have observed in perfused hearts from alloxan-diabetic rats
changes in hexose phosphate concentrations similar to those that we have seen in …
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