[HTML][HTML] Regulation of plasminogen activation on cell surfaces and fibrin
T Urano, FJ Castellino, Y Suzuki - Journal of Thrombosis and Haemostasis, 2018 - Elsevier
The fibrinolytic system dissolves fibrin and maintains vascular patency. Recent advances in
imaging analyses allowed visualization of the spatiotemporal regulatory mechanism of
fibrinolysis, as well as its regulation by other plasma hemostasis cofactors. Vascular
endothelial cells (VECs) retain tissue‐type plasminogen activator (tPA) after secretion and
maintain high plasminogen (plg) activation potential on their surfaces. As in plasma, the
serpin, plasminogen activator inhibitor type 1 (PAI‐1), regulates fibrinolytic potential via …
imaging analyses allowed visualization of the spatiotemporal regulatory mechanism of
fibrinolysis, as well as its regulation by other plasma hemostasis cofactors. Vascular
endothelial cells (VECs) retain tissue‐type plasminogen activator (tPA) after secretion and
maintain high plasminogen (plg) activation potential on their surfaces. As in plasma, the
serpin, plasminogen activator inhibitor type 1 (PAI‐1), regulates fibrinolytic potential via …
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