Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency
The Zap1 transcription factor is a central player in the response of yeast to changes in zinc
status. Previous studies identified over 80 genes activated by Zap1 in zinc-limited cells. In
this report, we identified 36 genes repressed in a zinc-and Zap1-responsive manner. As a
result, we have identified a new mechanism of Zap1-mediated gene repression whereby
transcription of the MET3, MET14, and MET16 genes is repressed in zinc-limited cells.
These genes encode the first three enzymes of the sulfate assimilation pathway. We found …
status. Previous studies identified over 80 genes activated by Zap1 in zinc-limited cells. In
this report, we identified 36 genes repressed in a zinc-and Zap1-responsive manner. As a
result, we have identified a new mechanism of Zap1-mediated gene repression whereby
transcription of the MET3, MET14, and MET16 genes is repressed in zinc-limited cells.
These genes encode the first three enzymes of the sulfate assimilation pathway. We found …
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