4 天前 - … cancer treatment. Limited understanding of tumor-specific deregulations and lack
of suitable drug … access of affected patients to precision-based oncology therapeutics. Here, …

4 天前 - … Diffuse Midline Gliomas (DMGs) present formidable challenges in neuro-oncology,
prompting the exploration of innovative therapeutic strategies. Repurposing approved drugs…

4 天前 - … In this study, we find that co-treatment with CDK9i and brain penetrant, FDA-approved
drugs targeting neurotransmitter signaling alters DMG transcription and reduces DMG …

4 天前 - … 1% as of May 2024, there is an urgent need for effective treatments. Kinase inhibitors,
traditionally used in cancer therapy, have emerged as promising candidates due to their …

10 天前 - Drug repurposing, also known as drug redirecting, is a novel approach to reuse
and explore an approved, failed, or abandoned drug and redirecting it toward a new …

10 天前 - … , including cancer. Drug repurposing for cancer therapy is currently a key topic
of study… It is a way of exploring recent therapeutic applications for already-existing drugs. …

11 天前 - … approved by FDA for cancer therapies in both mouse and human OPC-to-OL
differentiation systems. Trametinib, the first FDA approved … therapies or repurpose existing drugs …

11 天前 - … new therapeutic drug use that has received prior approval for clinical use [26]. Though,
repurposing the FDA-approved drugs as … In this study, FDA-approved compounds were …

11 天前 - … be used in functional drug formulations with drug repurposing … the anticancer
properties of antiepileptic drugs and … drugs might be a good option for adjuvant cancer therapy, but …

13 天前 - … Approved drugs have been established for eight candidate targets, which could
potentially be repurposed for PC therapies. The phenome-wide investigation revealed 12 …