4 天前 - … This study advances human induced pluripotent stem … toxicity screening in induced
pluripotent stem cell-derived cardiomyocytes and hepatocytes. Assay and drug development …

6 天前 - … successfully manipulating the pharmacokinetics of the … nanostructure and the
intrinsic biological activity of the multi-… of smart cationic lipids with lower toxicity, and containing …

10 天前 - … development of safer products. Computational tools can predict an active pharmaceutical
candidate's pharmacokinetic … a wide range of biological activities, including toxicity, for …

11 天前 - … , pharmacological activities and molecular mechanism, active derivatives, toxicity
and … , mechanism, active derivatives, pharmacokinetics and toxicity, and applications of POH …

11 天前 - … still in the early stages of the drug development process because no comprehensive
pharmacokinetic (PK) studies or long-term toxicity studies. Preclinical PK and toxicological …

11 天前 - … pharmacokinetic profile, a convincing complement inhibitory effect, and no observable
toxic effects… To improve the pharmacological properties and druggability, we herein fused …

12 天前 - … to WT-EGFR, thereby reducing toxicity and enabling the … expansive spectrum of
biological activities of Osimertinib and … and optimizing pharmacokinetic properties. This review …

12 天前 - … of therapeutics and improved pharmacokinetics. However, limitations such as toxicity,
poor … Quantum dots contain heavy metals, leading to toxicity. Biopolymeric nanoparticles …

14 天前 - … Nonetheless, poor pharmacokinetic properties including … by combined treatment,
and reduce drug toxicity of LVN … the tumor tissue to exert strong pharmacological activity. FR, a …

15 天前 - … development of new drugs is a lengthy and expensive process, due to the difficulty
of better understanding the pharmacokinetic and pharmacodynamic properties … the toxicity (…