8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.

AM Shah, HA Spurgeon, SJ Sollott, A Talo… - Circulation …, 1994 - Am Heart Assoc
the presence of isoproterenol (3 nmol/L). 8bcGMP had no effect on cytosolic pH in cells (n=4)
loaded with the … diastolic tone by reducing the relative myofilament response to Ca2+, prob…

MD-2 as the target of curcumin in the inhibition of response to LPS

H Gradišar, MM Keber, P Pristovšek… - Journal of Leucocyte …, 2007 - academic.oup.com
… affinity to the myeloid differentiation protein 2 (MD-2), which is the LPS-binding component
of the … shift toward the blue upon the addition of MD-2, indicating the transfer of curcumin into …

Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti–PD-1 therapy

JM Taube, A Klein, JR Brahmer, H Xu, X Pan… - Clinical cancer …, 2014 - AACR
The current study expands on this … to each other and to clinical response to anti–PD-1 (nivolumab).
Significant associations were found among tumor cell PD-L1 expression, the

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

X Huang, F Venet, YL Wang… - Proceedings of the …, 2009 - National Acad Sciences
… bacterial burden and suppressed inflammatory cytokine response. To the extent that this is
a macrophage-specific aspect of the effects of PD-1, we found the following: first, peritoneal …

Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine

VS Mattay, TE Goldberg, F Fera… - Proceedings of the …, 2003 - National Acad Sciences
the PFC, we deemed it necessary to control for other variables that also potentially contribute
to the cortical responseto variance in the fMRI data, but these must be minimized to identify …

CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy

AK McClendon, JL Dean, DB Rivadeneira, JE Yu… - Cell cycle, 2012 - Taylor & Francis
to the aggressive behavior of these tumors, loss of RB function was also shown to be associated
with improved response to … ated with improved response to chemotherapy, including regi…

A defective type 1 response to rhinovirus in atopic asthma

NG Papadopoulos, LA Stanciu, A Papi, ST Holgate… - Thorax, 2002 - thorax.bmj.com
… that the immune response to RVs is not uniquely of a type 1 phenotype, as previously suggested.
The type 1 response … specific to RV rather than a response to soluble factors in the virus …

Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo

RS Perlstein, MH Whitnall, JS Abrams… - …, 1993 - academic.oup.com
… All maximal ACTH responses at 2 h were similar. Therefore, we chose 1 pg LPS to study
the modulation of the 2 h ACTH response to LPS. The 4 h ACTH response was similar after 5-…

[HTML][HTML] PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction

T Oda, YO Jung, HS Kim, X Cai, JM López-Guisa… - Kidney international, 2001 - Elsevier
… In summary, up-regulated expression of PAI-1 in response to renal obstruction appears
to play an important role in the ensuing fibrogenic response. The results of the present study …

Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection

KI Happel, M Zheng, E Young, LJ Quinton… - The Journal of …, 2003 - journals.aai.org
The combination of our neutralization experiments and the time course of p19 induction in
vivo supports the hypothesis that IL-23 in response to … is a key proximal event leading to IL-17 …