Retinal Thickness Changes Over Time in a Murine AD Model APPNL-F/NL-F
E Salobrar-García, I López-Cuenca… - Frontiers in Aging …, 2021 - frontiersin.org
Background: Alzheimer's disease (AD) may present retinal changes before brain pathology,
suggesting the retina as an accessible biomarker of AD. The present work is a diachronic
study using spectral domain optical coherence tomography (SD-OCT) to determine the total
retinal thickness and retinal nerve fiber layer (RNFL) thickness in an APPNL− F/NL− F
mouse model of AD at 6, 9, 12, 15, 17, and 20 months old compared to wild type (WT)
animals. Methods: Total retinal thickness and RNFL thickness were determined. The mean …
suggesting the retina as an accessible biomarker of AD. The present work is a diachronic
study using spectral domain optical coherence tomography (SD-OCT) to determine the total
retinal thickness and retinal nerve fiber layer (RNFL) thickness in an APPNL− F/NL− F
mouse model of AD at 6, 9, 12, 15, 17, and 20 months old compared to wild type (WT)
animals. Methods: Total retinal thickness and RNFL thickness were determined. The mean …
Retinal Thickness Changes Over Time in a Murine AD Model APPNL-F/NL-F
ES García Martín, I López Cuenca, L Sánchez Puebla… - 2021 - docta.ucm.es
Background: Alzheimer's disease (AD) may present retinal changes before brain pathology,
suggesting the retina as an accessible biomarker of AD. The present work is a diachronic
study using spectral domain optical coherence tomography (SD-OCT) to determine the total
retinal thickness and retinal nerve fiber layer (RNFL) thickness in an APPNL− F/NL− F
mouse model of AD at 6, 9, 12, 15, 17, and 20 months old compared to wild type (WT)
animals. Methods: Total retinal thickness and RNFL thickness were determined. The mean …
suggesting the retina as an accessible biomarker of AD. The present work is a diachronic
study using spectral domain optical coherence tomography (SD-OCT) to determine the total
retinal thickness and retinal nerve fiber layer (RNFL) thickness in an APPNL− F/NL− F
mouse model of AD at 6, 9, 12, 15, 17, and 20 months old compared to wild type (WT)
animals. Methods: Total retinal thickness and RNFL thickness were determined. The mean …
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