Reversible regulation of promoter and enhancer histone landscape by DNA methylation in mouse embryonic stem cells
DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we
profile the DNA methylome, transcriptome, and global occupancy of histone modifications
(H3K4me1, H3K4me3, H3K27me3, and H3K27ac) in a series of mouse embryonic stem
cells (mESCs) with varying DNA methylation levels to study the effects of DNA methylation
on deposition of histone modifications. We find that genome-wide DNA demethylation alters
occupancy of histone modifications at both promoters and enhancers. This is reversed upon …
profile the DNA methylome, transcriptome, and global occupancy of histone modifications
(H3K4me1, H3K4me3, H3K27me3, and H3K27ac) in a series of mouse embryonic stem
cells (mESCs) with varying DNA methylation levels to study the effects of DNA methylation
on deposition of histone modifications. We find that genome-wide DNA demethylation alters
occupancy of histone modifications at both promoters and enhancers. This is reversed upon …
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