Many obese people take dietary and herbal supplements to reduce weight, and millions of dollars are spent on these products each year. The efficiency and safety of several supplements, however, remain under doubt. Supplements are thought to facilitate weight reduction by increasing energy expenditure, satiety, and fat oxidation, inhibiting dietary fat absorption, modulating carbohydrate metabolism, elevating fat excretion, boosting water excretion, and improving mood. Due to the area’s rapid development, this study provides an overview of the current research on a few dietary supplements, herbal combinations, and combination products. Further study is necessary to determine the effectiveness of several supplements because they have not been put to the test in randomized controlled trials. Patients should be guided through the use of dietary supplements by nutritionists and medical professionals, who should also report any unfavorable side effects to the FDA. The production, sale, and marketing of these supplements would be subject to additional regulations.