Background: Expanded HIV screening efforts in the United States have increased the use of
rapid HIV tests in emergency departments. The reported sensitivity and specificity of rapid
HIV tests exceed 99%. Objective: To assess whether a reactive rapid oral HIV test result
correctly identifies adults with HIV infection in the emergency department. Design:
Diagnostic test performance assessment within the framework of a randomized, clinical trial.
Setting: Brigham and Women's Hospital emergency department (Boston, Massachusetts) …

OF INTERNAL DOCUMENTS. Hill KP, Ross JS, Egilman DS, et al. Ann Intern Med 2008;
149: 251–8. This case study sought to describe a known seeding trial, a clinical study
conducted by a pharmaceutical company designed to fulfill marketing objectives. In this
case, the Merck & Co. seeding trial reviewed ADVANTAGE (Assessment of Differences
between Vioxx And Noproxen To Ascertain Gastrointestinal tolerability and Effectiveness)
using data elicited from two separate legal proceedings. The data included Merck internal …