Revisiting the L-Dopa response as a predictor of motor outcomes after deep brain stimulation in Parkinson's disease

Z Lin, X Zhang, L Wang, Y Zhang, H Zhou… - Frontiers in Human …, 2021 - frontiersin.org
L-dopa responsiveness following the L-dopa challenge test for predicting motor outcomes
… We also focused on revisiting the predictive value of preoperative L-dopa challenge …

Clinical factors and dopamine transporter availability for the prediction of outcomes after globus pallidus deep brain stimulation in Parkinson's disease

SH Lee, M Kim, J Lee, JW Kim, MS Kim, S Jo… - Scientific reports, 2022 - nature.com
… We aimed to investigate the predictive value of preoperative clinical factors and dopamine
transporter imaging for outcomes after globus pallidus interna (GPi) deep brain stimulation (…

Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson's disease

RM Köhler, TS Binns, T Merk, G Zhu, Z Yin, B Zhao… - brain, 2024 - academic.oup.com
… Our study showcases high prediction accuracies of motor 29 intention in cortical but not
subthalamic signals. In the future, decoding of movement intention 30 could inform adaptive …

The effect of L-dopa in Parkinson's disease as revealed by neurophysiological studies of motor and sensory functions

A Suppa, M Bologna, A Conte, A Berardelli… - Expert review of …, 2017 - Taylor & Francis
L-dopa dose, they detected no response to iTBS, whereas when patients took their full L-dopa
dose, both the response to … been treated by means of deep brain stimulation (DBS) of the …

Axial symptoms as main predictors of short-term subthalamic stimulation outcome in Parkinson's disease

CA Artusi, C Ledda, D Rinaldi, E Montanaro… - Journal of the …, 2023 - Elsevier
Deep brain stimulation (DBS) is an established therapeutic … an excellent response to
STN-DBS, at least in the first years after … preoperative axial response and the motor DBS outcome. …

Deep brain stimulation in Early Onset Parkinson's disease

P Krause, J Reimer, J Kaplan, F Borngräber… - Frontiers in …, 2022 - frontiersin.org
… in possible predictors for the putative DBS outcome in a cohort … ICB is observed under higher
dosages of pulsatile L-Dopa … due to the more variable motor response in this small patient …

[HTML][HTML] The missing, the short, and the long: L-Dopa responses and dopamine actions

RL Albin, DK Leventhal - Annals of neurology, 2017 - ncbi.nlm.nih.gov
prediction is that the LDR should be specific for L-dopa and not occur with dopamine agonists.
This prediction … observation that subthalamic or pallidal deep brain stimulation (DBS) in …

Motor and Non‐motor Outcomes of Deep Brain Stimulation across the Genetic Panorama of Parkinson's Disease: A Multi‐Scale Meta‐Analysis

E Asimakidou, G Xiromerisiou… - Movement Disorders …, 2024 - Wiley Online Library
l-Dopa response and UPDRS III (r = 0.603, P < 0.001). … of 380 gPD patients, we revisited the
question of DBS efficacy in … be more relevant when predicting DBS outcomes, although this …

Bilateral globus pallidus interna deep brain stimulation in Parkinson's disease: Therapeutic effects and motor outcomes prediction in a short-term follow up

D Shen, L Cao, Y Ling, D Li, K Ren, W Shi… - Frontiers in Human …, 2023 - frontiersin.org
… symptoms between the MedOff and MedOn states, L-dopa responsiveness, PD motor
identified the following preoperative clinical factors predictive of short-term motor response: L-dopa

Pre-operative cognitive burden as predictor of motor outcome following bilateral subthalamic nucleus deep brain stimulation in Parkinson's disease

V Tang, XL Zhu, C Lau, A Chan, K Ma, J Yeung… - Neurological …, 2022 - Springer
… was found to be positively associated with fall risks and motor dysfunctions [10]; suboptimal
levodopa response at baseline was found to have a higher risk of cognitive decline …