Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron
K Honda, MA Smith, X Zhu, D Baus, WC Merrick… - Journal of Biological …, 2005 - ASBMB
Oxidative modification of cytoplasmic RNA in vulnerable neurons is an important, well
documented feature of the pathophysiology of Alzheimer disease. Here we report that RNA-
bound iron plays a pivotal role for RNA oxidation in vulnerable neurons in Alzheimer
disease brain. The cytoplasm of hippocampal neurons showed significantly higher redox
activity and iron (II) staining than age-matched controls. Notably, both were susceptible to
RNase, suggesting a physical association of iron (II) with RNA. Ultrastructural analysis …
documented feature of the pathophysiology of Alzheimer disease. Here we report that RNA-
bound iron plays a pivotal role for RNA oxidation in vulnerable neurons in Alzheimer
disease brain. The cytoplasm of hippocampal neurons showed significantly higher redox
activity and iron (II) staining than age-matched controls. Notably, both were susceptible to
RNase, suggesting a physical association of iron (II) with RNA. Ultrastructural analysis …
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