Rigidity of collagen fibrils controls collagen gel-induced down-regulation of focal adhesion complex proteins mediated by α2β1 integrin
Previous studies have shown that collagen gel overlay induced selective proteolysis of focal
adhesion complex proteins in Madin-Darby canine kidney (MDCK) cells. In this study, we
examined whether morphological and biochemical changes were present in cells cultured
on collagen gel. We found that focal adhesion complex proteins, including focal adhesion
kinase (FAK), talin, paxillin, and p130 cas, but not vinculin, were decreased within 1 h when
MDCK cells were cultured on collagen gel. Collagen gel-induced selective decrease of focal …
adhesion complex proteins in Madin-Darby canine kidney (MDCK) cells. In this study, we
examined whether morphological and biochemical changes were present in cells cultured
on collagen gel. We found that focal adhesion complex proteins, including focal adhesion
kinase (FAK), talin, paxillin, and p130 cas, but not vinculin, were decreased within 1 h when
MDCK cells were cultured on collagen gel. Collagen gel-induced selective decrease of focal …
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