ContextSouth Asians have high rates of acute myocardial infarction (AMI) at younger ages
compared with individuals from other countries but the reasons for this are unclear.
ObjectiveTo evaluate the association of risk factors for AMI in native South Asians, especially
at younger ages, compared with individuals from other countries. Design, Setting, and
ParticipantsStandardized case-control study of 1732 cases with first AMI and 2204 controls
matched by age and sex from 15 medical centers in 5 South Asian countries and 10 728 …

To the Editor: As authors of the Assessment of Pexelizumab in Acute Myocardial Infarction
(APEX AMI) trial, 1 and on behalf of the APEX AMI study group, we believe that the
accompanying Editorial by Drs Eikelboom and O'Donnell2 raises 3 issues deserving
clarification. First, the Editorial questions the rationale for targeting one half of the original
number of anticipated events. Prior to unblinding the results, we reported3 that the rationale
was based in part on the prior systematic overview. 4 When combined with the results from …