… Before turning to a discussion of the pathogenesis of CF airway disease, we review the
clinical turning points to place the subsequent discussion of ASL within a broader context. …

… that CFTR dysfunction may play a role in other common airways … CFTR dysfunction, with
an emphasis on COPD, and the possibility of CFTR-specific treatment in other airway diseases. …

… Another hallmark of CF airway disease that is also found in COPD is the accumulation of …
In conclusion, CFTR has a fundamental role in the physiology of the airways. It is involved …

… , suggesting that lessons learned from CF may be applicable to common airway diseases …
Given the key role of CFTR in proper mucociliary clearance and airway defence, the obvious …

… CFTR protein dysfunction is common in both the CF and COPD airways. This review provides
… update of our understanding of the role of dysfunctional CFTR in both respiratory diseases. …

… Here we discuss the arguments for and against the role … airways showed enhanced sodium
absorption and the mice exhibited the clinical features of CF airway disease including airway …

… to prevent infection-associated exacerbations of airway disease. In addition, anti-inflammatory …
This review examines the role of CFTR protein dysfunction in disorders of the respiratory …

… of CFTR modulators on airway inflammation, infection, and their influence on the impaired
pulmonary host defences associated with CF lung disease. We also consider the role of …

… To date, data suggest that CFTR modulators have a potential role in the prevention and
treatment of airway infections through both direct and indirect mechanisms. However, whether …

… roles of CFTR in these processes, highlighting how they can contribute to novel therapeutic
strategies. However, such roles are … chronic airway diseases [189]. A possible involvement of …