Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice
Obesity results in the chronic activation of innate immune system and subsequently sets in
diabetes. Aim of the study was to investigate the immunometabolic role of brown adipose
tissue (BAT) in the obesity. We performed both BAT transplantation as well as extirpation
experiments in the mouse model of high-fat diet (HFD)-induced obesity. We carried out
immune cell profiling in the stromal vascular fraction (SVF) isolated from epididymal white
adipose tissue (eWAT). BAT transplantation reversed HFD-induced increase in body weight …
diabetes. Aim of the study was to investigate the immunometabolic role of brown adipose
tissue (BAT) in the obesity. We performed both BAT transplantation as well as extirpation
experiments in the mouse model of high-fat diet (HFD)-induced obesity. We carried out
immune cell profiling in the stromal vascular fraction (SVF) isolated from epididymal white
adipose tissue (eWAT). BAT transplantation reversed HFD-induced increase in body weight …
Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice.
KS Kripa Shankar, DK Durgesh Kumar… - 2019 - cabidigitallibrary.org
Obesity results in the chronic activation of innate immune system and subsequently sets in
diabetes. Aim of the study was to investigate the immunometabolic role of brown adipose
tissue (BAT) in the obesity. We performed both BAT transplantation as well as extirpation
experiments in the mouse model of high-fat diet (HFD)-induced obesity. We carried out
immune cell profiling in the stromal vascular fraction (SVF) isolated from epididymal white
adipose tissue (eWAT). BAT transplantation reversed HFD-induced increase in body weight …
diabetes. Aim of the study was to investigate the immunometabolic role of brown adipose
tissue (BAT) in the obesity. We performed both BAT transplantation as well as extirpation
experiments in the mouse model of high-fat diet (HFD)-induced obesity. We carried out
immune cell profiling in the stromal vascular fraction (SVF) isolated from epididymal white
adipose tissue (eWAT). BAT transplantation reversed HFD-induced increase in body weight …