▪ Abstract Vascular endothelium is strategically located at the interface between tissue and
blood. It is pivotal for protecting against vascular injury and maintaining blood fluidity.
Normal endothelium releases prostacyclin and nitric oxide, potent inhibitors of platelet and
monocyte activation and vasodilators. Their syntheses are governed by isoforms of
enzymes. Normal endothelial surface expresses ecto-adenosine diphosphatase, which
degrades adenosine diphosphate and inhibits platelet aggregation; thrombomodulin, which …