[HTML][HTML] Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy
Background Variable heavy chain (VH) family frameworks (FWRs) have been reported to
affect antibody receptor and superantigen binding; however, such effects in IgE remain
largely unknown. Given that VH family biases have been previously reported in IgE of
certain allergies, there is a need to investigate this phenomenon for biotechnological and
therapeutic purposes. Objective We sought to investigate the effects of VH families on IgE
interaction with FcεRIα, anti-IgE omalizumab, antigen, and superantigen protein A (spA) by …
affect antibody receptor and superantigen binding; however, such effects in IgE remain
largely unknown. Given that VH family biases have been previously reported in IgE of
certain allergies, there is a need to investigate this phenomenon for biotechnological and
therapeutic purposes. Objective We sought to investigate the effects of VH families on IgE
interaction with FcεRIα, anti-IgE omalizumab, antigen, and superantigen protein A (spA) by …
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