… The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and
alterations of its function … By regulating intraneuronal chloride homeostasis, KCC2 strongly …

… The K-Cl cotransporter KCC2 has two entirely independent biological actions as either an
… KCC2 plays a crucial role in dendritic spine formation Studies on neuronal K-Cl cotransport …

… : Na+-K+—2 Cl– and K+—Cl–, respectively. Each co-transporter can potentially move ions in
either … : both NKCC1 and KCC2 play a critical role in the formation of the neuronal network. …

… K + -Cl − co-transporter 2 (KCC2/SLC12A5) is a neuronal … and glycine to exert inhibitory
neurotransmission through its Cl − … This developmental excitatory-inhibitory switch has important …

… of the electroneutral K + -Cl − cotransporter KCC2, a member of the … Cl − homeostasis and
GABAergic neurotransmission. As … in KCC2 functional expression after prolonged inhibition of …

… This constitutes the main role of GABA in CNS neurotransmission; its potential dysfunction
… of the neuron-specific K–Cl cotransporter KCC2. The mouse KCC2 co-transporter consists of …

… neurons that use glycine as an inhibitory neurotransmitter, a … (excitatory) responses, but
later it produces hyperpolarizing (… in expression of the K + -Cl – cotransporter KCC2. These …

… inhibitory NT in intrinsic neurons of the brain where it acts to regulate excitatory neurotransmission
[… In isotonic conditions, KCC2 maintains K-Cl cotransport due to its unique C-terminal …

… K–Cl cotransporter KCC2 establishes the low intraneuronal Cl – levels required for the
hyperpolarizing inhibitory … phosphorylation have been associated with impaired KCC2 function in …

… that the neuron-specific K + -Cl − cotransporter (KCC2) was … their involvement in inhibitory
neurotransmission further, but … As we explain below, GABA can be excitatory or inhibitory …