[HTML][HTML] Roles of APOBEC3A and APOBEC3B in human papillomavirus infection and disease progression
The apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3
(APOBEC3) family of cytidine deaminases plays an important role in the innate immune
response to viral infections by editing viral genomes. However, the cytidine deaminase
activity of APOBEC3 enzymes also induces somatic mutations in host genomes, which may
drive cancer progression. Recent studies of human papillomavirus (HPV) infection and
disease outcome highlight this duality. HPV infection is potently inhibited by one family …
(APOBEC3) family of cytidine deaminases plays an important role in the innate immune
response to viral infections by editing viral genomes. However, the cytidine deaminase
activity of APOBEC3 enzymes also induces somatic mutations in host genomes, which may
drive cancer progression. Recent studies of human papillomavirus (HPV) infection and
disease outcome highlight this duality. HPV infection is potently inhibited by one family …
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