Ethno-botanical and ethno-pharmacological studies of Rubia cordifolia continue to attract investigators for research work globally. Rubia cordifolia commonly known as Manjistha or Indian madder is an important medicinal plant growing up to 3500 meters height. Rubiae Radix (dried roots of Rubia cordifolia, Rubiaceae) is a rich source of anthraquinones responsible for its traditional, phytochemical and pharmacological activities. Today clinical investigations of herbal formulations and their market preparations, both are on demanding because of better safety and efficacy without or minimal side effects. This review summarizes the concept of finding new approach to treat cardiac disorders on the basis of previous reports of this plant.