Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis
Objective Mercury is a global environmental pollutant and is responsible for several organ
pathophysiology including oxidative stress-induced liver disorders. Therefore, the present
study was conducted to evaluate the potential ameliorative effects of rutin on mercury
chloride (HgCl 2)-induced hepatotoxicity in adult male rats. Methods HgCl 2 was
intraperitoneally injected at a dose of 1.23 mg/kg body weight for 7 days alone or in
combination with the orally rutin (50 and 100 mg/kg body weight). Results Rutin treatment …
pathophysiology including oxidative stress-induced liver disorders. Therefore, the present
study was conducted to evaluate the potential ameliorative effects of rutin on mercury
chloride (HgCl 2)-induced hepatotoxicity in adult male rats. Methods HgCl 2 was
intraperitoneally injected at a dose of 1.23 mg/kg body weight for 7 days alone or in
combination with the orally rutin (50 and 100 mg/kg body weight). Results Rutin treatment …
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