S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression
DA Skoufias, S DeBonis, Y Saoudi, L Lebeau… - Journal of biological …, 2006 - ASBMB
Human Eg5, responsible for the formation of the bipolar mitotic spindle, has been identified
recently as one of the targets of S-trityl-l-cysteine, a potent tumor growth inhibitor in the NCI
60 tumor cell line screen. Here we show that in cell-based assays S-trityl-l-cysteine does not
prevent cell cycle progression at the S or G 2 phases but inhibits both separation of the
duplicated centrosomes and bipolar spindle formation, thereby blocking cells specifically in
the M phase of the cell cycle with monoastral spindles. Following removal of S-trityl-l …
recently as one of the targets of S-trityl-l-cysteine, a potent tumor growth inhibitor in the NCI
60 tumor cell line screen. Here we show that in cell-based assays S-trityl-l-cysteine does not
prevent cell cycle progression at the S or G 2 phases but inhibits both separation of the
duplicated centrosomes and bipolar spindle formation, thereby blocking cells specifically in
the M phase of the cell cycle with monoastral spindles. Following removal of S-trityl-l …
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