SBDD and Its Challenges

S Chakraborti, S Sachchidanand - Current Trends in Computational …, 2023 - Springer
… and modulate its functions, resulting in therapeutic benefit. In this chapter, we provide an
overview of computational SBDD workflow, and the various challenges associated with it. We …

Structure-based drug design strategies and challenges

X Wang, K Song, L Li, L Chen - Current Topics in Medicinal …, 2018 - ingentaconnect.com
… Here we present an overview of SBDD used in drug discovery and highlight its recent …
Here we present a review of SBDD that highlighting the challenges and perspective of SBDD in …

Application of SBDD to the discovery of new antibacterial drugs

J Finn - Structure-based drug discovery, 2012 - Springer
… the objects of SBDD campaigns are described and the role of SBDD in the … SBDD programs
in the area, the targets selected in this chapter were selected to exemplify specific challenges

Ligand and Structure-Based Drug Design (LBDD and SBDD): Promising Approaches to Discover New Drugs

IJ dos Santos Nascimento… - Applied Computer-Aided …, 2023 - books.google.com
… Traditionally, SBDD is preferred by the scientific community mainly due to the easy … it is
challenging to obtain 10000 different varieties of a single chemical scaffold, as many times it

Structure-based drug design (SBDD)

G Rakshit, S Murtuja, BK Kumar, S Murugesan… - Computer aided drug …, 2022 - Elsevier
SBDD; … SBDD and the various tools employed, ie, AutoDock and Desmond, Schrödinger.
We hope we will be able to provide the readers a greater insight into the concepts of SBDD

[HTML][HTML] Systematic review on role of structure based drug design (SBDD) in the identification of anti-viral leads against SARS-Cov-2

NG Bajad, S Rayala, G Gutti, A Sharma, M Singh… - Current Research in …, 2021 - Elsevier
SBDD has gained momentum as the essential tool for faster and costeffective lead … success
of SBDD. This systematic review provides an overview of the novel coronavirus, its pathology …

[HTML][HTML] Computer-aided drug design using the fragment molecular orbital method: Current status and future applications for SBDD

D Takaya - Chemical and Pharmaceutical Bulletin, 2024 - jstage.jst.go.jp
… In structure-based drug design (SBDD), including inhibitor … Fragmentation method makes
it possible to apply the quantum … In this review, we outline the recent developments in SBDD

Structure-based drug designing

S Pant, S Verma, RK Pathak, DB Singh - Bioinformatics, 2022 - Elsevier
… Here, we provide a summary of the SBDD used in the discovery of drugs and highlight …
picture is complex so it is a challenging task for the selection of potential drug targets. It should be …

Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?

M Marín, M López, L Gallego‐Yerga… - Medicinal Research …, 2024 - Wiley Online Library
… These endeavors have met with significant challenges in every one of these expectations …
drug design (SBDD) has been pushed towards an alternative paradigm where it has been …

Leveraging SBDD in protein therapeutic development: antibody engineering

GL Gilliland, J Luo, O Vafa, JC Almagro - Structure-Based Drug Discovery, 2012 - Springer
… Further description of the antibody structure focuses on the IgG class, since this is the primary
form that is engineered to produce therapeutic antibodies and it is the class that we have …