SGLT2 inhibitors and incretin agents: associations with alanine aminotransferase activity in type 2 diabetes
Aim The impact of new classes of glucose lowering medications on markers of non-alcoholic
fatty liver disease (NAFLD) associated with type 2 diabetes (T2D) have been inconsistent in
their magnitude and independence. This large retrospective study investigates changes in
alanine aminotransferase (ALT) levels among subjects initiated on newer classes of T2D
medications in comparison to a reference control group. Methods We studied people with
T2D from a large Canadian diabetes register, who had canagliflozin, dapagliflozin …
fatty liver disease (NAFLD) associated with type 2 diabetes (T2D) have been inconsistent in
their magnitude and independence. This large retrospective study investigates changes in
alanine aminotransferase (ALT) levels among subjects initiated on newer classes of T2D
medications in comparison to a reference control group. Methods We studied people with
T2D from a large Canadian diabetes register, who had canagliflozin, dapagliflozin …
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