SIRT3 consolidates heterochromatin and counteracts senescence
Abstract Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of
physiological and pathological processes, including aging and aging-related diseases.
However, the role of SIRT3 in regulating human stem cell homeostasis remains unclear.
Here we found that SIRT3 expression was downregulated in senescent human
mesenchymal stem cells (hMSCs). CRISPR/Cas9-mediated depletion of SIRT3 led to
compromised nuclear integrity, loss of heterochromatin and accelerated senescence in …
physiological and pathological processes, including aging and aging-related diseases.
However, the role of SIRT3 in regulating human stem cell homeostasis remains unclear.
Here we found that SIRT3 expression was downregulated in senescent human
mesenchymal stem cells (hMSCs). CRISPR/Cas9-mediated depletion of SIRT3 led to
compromised nuclear integrity, loss of heterochromatin and accelerated senescence in …
[引用][C] SIRT3 CONSOLIDATES HETEROCHROMATIN AND COUNTERACTS SENESCENCE
D Zhiqing, J Qianzhao, W Zeming, Z Weiqi, C Yusheng… - 2021 - ir.ioz.ac.cn
中国科学院动物研究所机构知识库(CAS OpenIR): SIRT3 CONSOLIDATES
HETEROCHROMATIN AND COUNTERACTS SENESCENCE …
HETEROCHROMATIN AND COUNTERACTS SENESCENCE …
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