Aims Conflicting results have been reported in the literature on the potential antiarrhythmic
effect of sacubitril/valsartan in heart failure patients with reduced ejection fraction (HFrEF).
The objectives of this study were: 1-to evaluate the long term effects of sacubitril/valsartan on
arrhythmic burden in HFrEF patients; 2-to evaluate the correlation between the reduction of
premature ventricular complexes during f-up and reverse remodelling. Methods We
identified 255 consecutive HFrEF patients treated with sacubitril/valsartan between March …