[HTML][HTML] Safety of combined PD-1 pathway inhibition and intracranial radiation therapy in nonsmall cell lung cancer

HG Hubbeling, EF Schapira, NK Horick… - … of Thoracic Oncology, 2018 - Elsevier
PD-1 pathway inhibition in combination were overall well tolerated in the study population.
No … were observed between PD-1 pathway inhibitor-naive and PD-1 inhibitor-treated patients. …

Safety of combined PD1 pathway inhibition and radiation therapy for nonsmallcell lung cancer: A multicentric retrospective study from the GFPC

P Lesueur, A Escande, J Thariat, E Vauléon… - Cancer …, 2018 - Wiley Online Library
… on combining checkpoint … PD-1 inhibition combined with irradiation led to fewer tumor-infiltrating
myeloid-derived suppressor cells in the lesion's microenvironment and that anti-PD-1

… and safety of combining anti-angiogenic therapy, radiotherapy, and PD-1 inhibitors in patients with driver gene-negative non-small cell lung cancer brain metastases …

X Zhang, Q Sun, R Chen, MD Zhao, F Cai, Z Cui… - BMC cancer, 2024 - Springer
radiation therapy combined with immunotherapy or targeted … renal cell carcinoma ceased
using cabozantinib—a multi-target inhibitor of angiogenesis, C-MET, RET, and other pathways

Safety of combining radiotherapy with immune-checkpoint inhibition

WL Hwang, LRG Pike, TJ Royce, BA Mahal… - … Clinical oncology, 2018 - nature.com
… (IMRT), stereotactic body radiation therapy, and stereotactic radiosurgery are sophisticated
… of combining radiotherapy with simultaneous inhibition of the CTLA-4 and PD-L1 pathways. …

Treatment-related adverse events of PD-1 and PD-L1 inhibitor-based combination therapies in clinical trials: a systematic review and meta-analysis

X Zhou, Z Yao, H Bai, J Duan, Z Wang, X Wang… - … Lancet Oncology, 2021 - thelancet.com
PD-1 and PD-L1 signalling pathwaysafety concerns, there is an urgent need to
comprehensively understand the toxicity profiles of PD-1 or PD-L1 inhibitor-based combination

Stereotactic body radiotherapy in combination with non-frontline PD-1 inhibitors and targeted agents in metastatic renal cell carcinoma

Y Liu, Z Zhang, R Liu, W Wei, Z Zhang, L Mai, S Guo… - Radiation …, 2021 - Springer
… The NIVES trail has only observed an ORR of 19% in patients receiving nivolumab plus …
on the safety and efficacy of combining SBRT with non-first-line PD-1 inhibitors and targeted …

Rethinking pulmonary toxicity in advanced non-small cell lung cancer in the era of combining anti-PD-1/PD-L1 therapy with thoracic radiotherapy

M Li, L Gan, A Song, J Xue, Y Lu - … et Biophysica Acta (BBA)-Reviews on …, 2019 - Elsevier
… from preclinical data and summarizing safety data from relevant … trials combining RT and
PD-1/PD-L1 inhibitors (Table 1) … from the combination of radiation therapy with immunotherapy …

Combination strategies with PD-1/PD-L1 blockade: current advances and future directions

M Yi, X Zheng, M Niu, S Zhu, H Ge, K Wu - Molecular cancer, 2022 - Springer
low response rate of α-PD-1/PD-L1 therapy remains to be resolved. For most cancer patients,
PD-1/PD-L1 pathway is not … , radiotherapy, angiogenesis inhibitors, targeted therapy, other …

Efficacy and safety of PD1/PDL1 inhibitors combined with radiotherapy and anti-angiogenic therapy for solid tumors: A systematic review and meta-analysis

F Xian, J Wu, L Zhong, G Xu - Medicine, 2023 - journals.lww.com
… can overcome the upregulated inhibitory pathways and molecules triggered by RT, thereby
… and safety of anti-PD1/PDL1 combined with RT and anti-angiogenic agents in the treatment

SBRT combined with PD-1/PD-L1 inhibitors in NSCLC treatment: a focus on the mechanisms, advances, and future challenges

Y Chen, M Gao, Z Huang, J Yu, X Meng - … of hematology & oncology, 2020 - Springer
… body radiation therapy (SBRT), as a novel radiotherapy modality … could block the negative
regulatory pathway, which further … safety of the combination remains to be further investigated. …