Sarcopenia—consequences, mechanisms, and potential therapies
LJS Greenlund, KS Nair - Mechanisms of ageing and development, 2003 - Elsevier
Increasingly, the worldwide population is growing older. Sarcopenia occurs with age and is
characterized by loss of muscle mass, strength and endurance. Mechanisms that underlie
this process are beginning to be understood. These include age-related loss and atrophy of
individual muscle fibers, decreased synthesis of muscle proteins, and reduced mitochondrial
function. The role of decreased anabolic hormone production in causing these changes
remains to be clearly defined. Anabolic hormone replacement is a potential strategy …
characterized by loss of muscle mass, strength and endurance. Mechanisms that underlie
this process are beginning to be understood. These include age-related loss and atrophy of
individual muscle fibers, decreased synthesis of muscle proteins, and reduced mitochondrial
function. The role of decreased anabolic hormone production in causing these changes
remains to be clearly defined. Anabolic hormone replacement is a potential strategy …
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