Satietogenic Protein from Tamarind Seeds Decreases Food Intake, Leptin Plasma and CCK-1r Gene Expression in Obese Wistar Rats
IS Costa, AF Medeiros, FMC Carvalho, VCO Lima… - Obesity Facts, 2018 - karger.com
IS Costa, AF Medeiros, FMC Carvalho, VCO Lima, RP Serquiz, AC Serquiz, VN Silbiger…
Obesity Facts, 2018•karger.comObjective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from
Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and
leptin in obese Wistar rats. Methods: Three groups of obese rats were fed 10 days one of the
following diets: Standard diet (Labina®)+ water; High Glycemic Index and Load (HGLI) diet+
water or HGLI diet+ TTI. Lean animals were fed the standard diet for the 10 days. Food
intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of …
Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and
leptin in obese Wistar rats. Methods: Three groups of obese rats were fed 10 days one of the
following diets: Standard diet (Labina®)+ water; High Glycemic Index and Load (HGLI) diet+
water or HGLI diet+ TTI. Lean animals were fed the standard diet for the 10 days. Food
intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of …
Abstract
Objective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats. Methods: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Lean animals were fed the standard diet for the 10 days. Food intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of intestinal CCK-related genes, and expression of the ob gene in subcutaneous adipose tissue were assessed. Results: TTI decreased food intake but did not increase plasma CCK in obese animals. On the other hand, TTI treatment decreased CCK-1R gene expression in obese animals compared with the obese group with no treatment (p = 0.027). Obese animals treated with TTI presented lower plasma leptin than the non-treated obese animals. Conclusion: We suggest that TTI by decreasing plasma leptin may improve CCK action, regardless of its increase in plasma from obese rats, since food intake was lowest.
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