Selective inference in complex research

Y Benjamini, R Heller… - … Transactions of the …, 2009 - royalsocietypublishing.org
Philosophical Transactions of the Royal Society A …, 2009royalsocietypublishing.org
We explain the problem of selective inference in complex research using a recently
published study: a replicability study of the associations in order to reveal and establish risk
loci for type 2 diabetes. The false discovery rate approach to such problems will be
reviewed, and we further address two problems:(i) setting confidence intervals on the size of
the risk at the selected locations and (ii) selecting the replicable results.
We explain the problem of selective inference in complex research using a recently published study: a replicability study of the associations in order to reveal and establish risk loci for type 2 diabetes. The false discovery rate approach to such problems will be reviewed, and we further address two problems: (i) setting confidence intervals on the size of the risk at the selected locations and (ii) selecting the replicable results.
royalsocietypublishing.org
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