Selegiline in narcolepsy

SE Roselaar, N Langdon, CB Lock, P Jenner… - Sleep, 1986 - academic.oup.com
… the widespread investigation of MAO inhibitors in narcolepsy. We report the effects of
selegiline, 20-30 mg daily, given over a 4-week period to 21 subjects with narcolepsy-cataplexy. …

Selegiline in the treatment of narcolepsy

C Hublin, M Partinen, EH Heinonen, P Puukka… - Neurology, 1994 - AAN Enterprises
… improvement in narcoleptic symptoms and … , selegiline alleviates both main symptoms of
narcolepsy-the abnormal sleep tendency and cataplexy. Thus, treatment with selegiline makes it …

REM changes in narcolepsy with selegiline

LW Reinish, JG MacFarlane, P Sandor, CM Shapiro - Sleep, 1995 - academic.oup.com
… efficacious in the treatment of narcolepsy; however, side effects … of narcolepsy, we have used
a novel MAO inhibitor, selegiline… mechanism of action of selegiline in narcolepsy and sleep. …

Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases

M Ebadi, H Brown-Borg, J Ren, S Sharma… - Current Drug …, 2006 - ingentaconnect.com
Selegiline has been shown to be efficacious in Parkinson's disease, global ischemia, Gille de
la Tourette syndrome, and narcolepsy… , short term studies of selegiline suggest a beneficial …

Mechanism of action of narcolepsy medications

CR Gowda, LP Lundt - CNS spectrums, 2014 - cambridge.org
Selegiline is normally dosed at 10–40mg to treat narcoleptic symptoms. Since selegiline
associated with tyramine would be to use a selegiline patch. Since the drug would be delivered …

New developments in the management of narcolepsy

VC Abad, C Guilleminault - Nature and science of sleep, 2017 - Taylor & Francis
… of narcolepsy’s strong association with HLA DQB1*06-02, and genome-wide association
studies have identified polymorphisms in T-cell receptor loci. Narcolepsy … for narcolepsy include …

Narcolepsy

C Bassetti - Current Treatment Options in Neurology, 1999 - Springer
Opinion statement Narcolepsy is a disabling, chronic sleep-wake disorder that typically starts
in a patient’s second or third decade of life. Its key features are hypersomnia and cataplexy. …

Neuroprotective actions of selegiline

M Ebadi, S Sharma, S Shavali… - Journal of …, 2002 - Wiley Online Library
… In addition to being beneficial in patients with PD, selegiline is efficacious in Alzheimer's
disease, global ischemia, narcolepsy, and Gilles de la Tourette syndrome. However, …

Narcolepsy: current treatment options and future approaches

M Billiard - Neuropsychiatric disease and treatment, 2008 - Taylor & Francis
… the conventional treatment of narcolepsy. Modafinil has replaced … It is metabolically
converted to desmethyl selegiline, l-… of selegiline to avoid the risk of hypertensive reactions. …

Narcolepsy: current drug treatment options

C Hublin - Cns Drugs, 1996 - Springer
… The impact of narcolepsy on the patient's everyday life is con… with selegiline giving a subjective
improvement in 7Y1c of patients… than selegiline in increasing sleep latencies on the MWT. …