Polymers undergoing controlled degradation are of significant current interest. Among the
classes of degradable polymers, self-immolative polymers (SIPs) are attracting increasing
attention due to their ability to completely depolymerize from end to end following the
cleavage of their endcap or backbone. Their amplified responses to stimuli, along with their
ability to readily tune the stimulus to which they respond by changing only their endcap, are
useful features for a variety of applications. This review covers the major classes of SIPs …