Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2‐macroglobulin and tau: A population‐based autopsy study
M Tanskanen, T Peuralinna, T Polvikoski… - Annals of …, 2008 - Taylor & Francis
M Tanskanen, T Peuralinna, T Polvikoski, IL Notkola, R Sulkava, J Hardy, A Singleton…
Annals of medicine, 2008•Taylor & FrancisBackground. Senile systemic amyloidosis (SSA) is characterized by deposition of wild‐type
transthyretin (TTR)‐based amyloid in parenchymal organs in elderly individuals. Previously,
no population‐based studies have been performed on SSA. Methods. Here we have studied
the prevalence and risk factors for SSA in a Finnish autopsied population aged 85 or over,
as part of the population‐based Vantaa 85+ Autopsy Study (n= 256). The diagnosis of SSA
was based on histological examination of myocardial samples stained with Congo red and …
transthyretin (TTR)‐based amyloid in parenchymal organs in elderly individuals. Previously,
no population‐based studies have been performed on SSA. Methods. Here we have studied
the prevalence and risk factors for SSA in a Finnish autopsied population aged 85 or over,
as part of the population‐based Vantaa 85+ Autopsy Study (n= 256). The diagnosis of SSA
was based on histological examination of myocardial samples stained with Congo red and …
Background. Senile systemic amyloidosis (SSA) is characterized by deposition of wild‐type transthyretin (TTR)‐based amyloid in parenchymal organs in elderly individuals. Previously, no population‐based studies have been performed on SSA.
Methods. Here we have studied the prevalence and risk factors for SSA in a Finnish autopsied population aged 85 or over, as part of the population‐based Vantaa 85+ Autopsy Study (n = 256). The diagnosis of SSA was based on histological examination of myocardial samples stained with Congo red and anti‐TTR immunohistochemistry. The genotype frequencies of 20 polymorphisms in 9 genes in subjects with and without SSA were compared.
Results. The prevalence of SSA was 25%. SSA was associated with age, myocardial infarctions, the G/G (Val/Val) genotype of the exon 24 polymorphism in the alpha2‐macroglobulin (α2M), and the H2 haplotype of the tau gene (P‐values 0.002, 0.004, 0.042, and 0.016).
Conclusion. This population‐based study shows that SSA is very common in old individuals, affecting one‐quarter of people aged over 85 years. Myocardial infarctions and variation in the genes for α2M and tau may be associated with SSA.
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