… splicing, cleavage, and peptide bond formation in ribosome … the ability to carry out
sequence-specific cleavage of all RNA … that are found in optimized individuals. Encircled …

… breaking peptide bonds are central to the fields of chemical biology, protein engineering, …
Gels were run under a constant voltage of 150 V for a minimum of 2 h to obtain optimal …

… 78 exhibits efficient and sequence-specific DNA intercalation … strong binding to Cu II , Ni II
, Pd II , Pt II , and Co II/III . 60l , 82 … This approach offers high tailorability for the optimization of …

… CCA end of the A-‐site tRNA, new peptide bond is formed by … hybrid state is a prerequisite
for the optimal EF-‐G catalyzed … in an GTP hydrolysis dependent manner. Translocation is one …

… The hydrolysis of ester and peptide bonds of molecules plays … In the optimized transition
state (T2 NM ), the ester bond is … study, hydrolysis of critical PET by the active site models of two …

… amino acids via peptide bonds replacing the normal … active domain of the enzyme has
a tendency to form covalent … of tags resulting in optimal immobilization of antibodies with …

… been optimized through evolution for the efficient hydrolysis … into the active sites of well
characterized hydrolytic proteins to … practical means for the sequence specific recognition of DNA. …

… generated by the same sequence-specific protease. Due to soft-… in the breakdown of the
peptide bonds. In the cleavage of the … and protein engineering to meet the expanding needs. …

… However, effect sizes are often low and frequent optimization … p53, we measured
sequence-specific binding to consensus … For Omp2a, following the Ni 2+ - NTA purification, the …

… inexpensive, easy to modify and can be sequence-specific. In … An optimal probe should have
the following characteristics: 1… Unlike many other metal ions, Ni 2+ and Co 2+ also quench …