Serenoa repens extract in the treatment of benign prostatic hyperplasia
P Geavlete, R Multescu… - Therapeutic advances in …, 2011 - journals.sagepub.com
P Geavlete, R Multescu, B Geavlete
Therapeutic advances in urology, 2011•journals.sagepub.comWe are experiencing a revival of interest in phytotherapeutic agents, both in Europe and
North America, especially as a consequence of patients' dissatisfaction with the adverse
effects of the medical alternatives. One of the most frequently prescribed and studied such
agents is Serenoa repens extract, derived from the berry of the dwarf palm tree. We aimed to
review the most important published data regarding this type of treatment for benign
prostatic hyperplasia. A review of the existing articles regarding the use of Serenoa repens …
North America, especially as a consequence of patients' dissatisfaction with the adverse
effects of the medical alternatives. One of the most frequently prescribed and studied such
agents is Serenoa repens extract, derived from the berry of the dwarf palm tree. We aimed to
review the most important published data regarding this type of treatment for benign
prostatic hyperplasia. A review of the existing articles regarding the use of Serenoa repens …
We are experiencing a revival of interest in phytotherapeutic agents, both in Europe and North America, especially as a consequence of patients’ dissatisfaction with the adverse effects of the medical alternatives. One of the most frequently prescribed and studied such agents is Serenoa repens extract, derived from the berry of the dwarf palm tree. We aimed to review the most important published data regarding this type of treatment for benign prostatic hyperplasia. A review of the existing articles regarding the use of Serenoa repens extracts for benign prostatic hyperplasia was performed. The articles were analysed with regard to their relevance, scientific value and the size of the evaluated series. Multiple mechanisms of action have been attributed to this extract, including antiandrogenic action, an anti-inflammatory/anti-oedematous effect, prolactin signal modulation, and an antiproliferative effect exerted through the inhibition of growth factors. Regarding efficacy, European Association of Urology guidelines state that Serenoa repens extracts significantly reduce nocturia in comparison with placebo. However, the guideline committee is unable to make specific recommendations about phytotherapy of male lower urinary tract symptoms owing to the heterogeneity of the products and the methodological problems associated with meta-analyses. Most of the published trials regarding Serenoa repens phytotherapy demonstrate a significant improvement of urinary status and a favourable safety profile. Also, some authors have credited it with giving a significant improvement in erectile function and decreasing complications following transurethral resection of the prostate, especially bleeding. The results of phytotherapy with Serenoa repens extracts are very promising. More high-quality, randomized, placebo-controlled studies are required in order to demonstrate without doubt the true therapeutic value of these products. Particular attention must be focused on differentiating between registered preparations, which are regulated as drugs, and those considered to be food supplements.
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