Serotonin antagonists induce anxiolytic and anxiogenic-like behavior in zebrafish in a receptor-subtype dependent manner
M Nowicki, S Tran, A Muraleetharan, S Markovic… - Pharmacology …, 2014 - Elsevier
Motor function and anxiety-like responses are easily quantifiable in zebrafish, a novel model
organism for behavioral pharmacology. Activation of serotonin receptors through the use of
selective agonists has been shown to alter anxiety-like behaviors in zebrafish. However, few
studies have examined the effect of blockade of specific serotonin receptors. In the current
study, we examine the effect of 4 serotonin receptor antagonists selective for 5-HT1 A, 5-HT1
B/D, 5-HT 2, and 5-HT 3 receptors on zebrafish motor and anxiety-like responses. Exposure …
organism for behavioral pharmacology. Activation of serotonin receptors through the use of
selective agonists has been shown to alter anxiety-like behaviors in zebrafish. However, few
studies have examined the effect of blockade of specific serotonin receptors. In the current
study, we examine the effect of 4 serotonin receptor antagonists selective for 5-HT1 A, 5-HT1
B/D, 5-HT 2, and 5-HT 3 receptors on zebrafish motor and anxiety-like responses. Exposure …
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