Serum α-fetoprotein screening for hepatoblastoma in children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia

CL Clericuzio, E Chen, DE McNeil, T O'Connor… - The Journal of …, 2003 - Elsevier
CL Clericuzio, E Chen, DE McNeil, T O'Connor, EH Zackai, L Medne, G Tomlinson…
The Journal of pediatrics, 2003Elsevier
An elevated risk of hepatoblastoma for children with Beckwith-Wiedemann syndrome or
isolated hemihyperplasia is well established. We describe five children with Beckwith-
Wiedemann syndrome or isolated hemihyperplasia for whom serial serum α-fetoprotein
screening, usually in combination with abdominal ultrasound, led to early detection of
hepatoblastoma.
An elevated risk of hepatoblastoma for children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia is well established. We describe five children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia for whom serial serum α-fetoprotein screening, usually in combination with abdominal ultrasound, led to early detection of hepatoblastoma.
Elsevier
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