Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell …
T Czarnowicki, J Gonzalez, A Shemer… - Journal of Allergy and …, 2015 - Elsevier
Background Past studies of blood T-cell phenotyping in patients with atopic dermatitis (AD)
have provided controversial results and were mostly performed before the identification of
TH 9, TH 17, and TH 22 T-cell populations in human subjects. Objective We sought to
quantify TH 1, TH 2, TH 9, TH 17, and TH 22 T-cell populations and corresponding CD8+ T-
cell subsets in both cutaneous lymphocyte antigen (CLA)–positive and CLA− T-cell subsets
in patients with AD and control subjects. Methods We studied 42 adults with severe AD …
have provided controversial results and were mostly performed before the identification of
TH 9, TH 17, and TH 22 T-cell populations in human subjects. Objective We sought to
quantify TH 1, TH 2, TH 9, TH 17, and TH 22 T-cell populations and corresponding CD8+ T-
cell subsets in both cutaneous lymphocyte antigen (CLA)–positive and CLA− T-cell subsets
in patients with AD and control subjects. Methods We studied 42 adults with severe AD …
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