Validated protein biomarkers are needed for assessing health trajectories, predicting and
subclassifying disease, and optimizing diagnostic and therapeutic clinical decision-making.
The sensitivity, specificity, accuracy, and precision of single or combinations of protein
biomarkers may be altered by differences in physiological states limiting the ability to
translate research results to clinically useful diagnostic tests. Aptamer based affinity assays
were used to test whether low abundant serum proteins differed based on age, sex, and fat …