The neuregulin-1 gene is widely expressed in the central nervous system and is associated
with increased risk for schizophrenia. Using an ethologically based approach, the
phenotype of neuregulin-1 heterozygous knockout mice was examined by revealing the
individual elements of behaviour in the murine repertoire over the prolonged course of
interaction with the environment. During initial exploration, neuregulin-1 mutants displayed a
phenotype characterized by increases in locomotion and rearing free, with sex-specific …