Energy efficiency and throughput are concerns for energy-harvesting cognitive radio networks. However, attaining the maximum level of both requires optimization of sensing duration, harvested energy, and transmission time. To obtain the optimal values of these multiple parameters and to maximize the average throughput and energy efficiency, a new hybrid technique for multi-objective optimization is proposed. This hybrid optimization algorithm incorporates a Shapley value and a game theoretic concept into metaheuristics. Here, particle swarm optimization grey wolf optimization (PSOGWO) is selected as the source for the advanced hybrid algorithm. The concept of the unbiased nature of wolves is also added to PSOGWO to make it more efficient. Multi-objective optimization is formulated by taking a deep look into combined spectrum sensing and energy harvesting in a cognitive radio network (CSSEH). The Pareto optimal solutions for the multi-objective optimization problem of energy efficiency and throughput can be obtained using PSOGWO by updating the velocity with the weights. In the proposed Shapley hybrid multi-objective optimization algorithm, we used Shapley values to set up the weights that, in turn, updated the velocities of the particles. This updated velocity increased the ability of particles to reach a global optimum rather than becoming trapped in local optima. The solution obtained with this hybrid algorithm is the Shapley–Pareto optimal solution. The proposed algorithm is also compared with state-of-the-art PSOGWO, unbiased PSOGWO, and GWO. The results show a significant level of improvement in terms of energy efficiency by 3.56% while reducing the sensing duration and increasing the average throughput by 21.83% in comparison with standard GWO.