… DNA mismatch repair in some colorectal cancers 3 . However, our understanding of the
mutational processes that cause somatic mutations in most cancer classes is remarkably limited. …

… models describing the signatures of mutational processes operative in cancer genomes and
… to decipher these mutational signatures. Here, by modeling mutational processes as a blind …

… MD Anderson Cancer Center Home MD Anderson Cancer Center Logo … Erratum:
Signatures of mutational processes in human cancer (Nature (2013) 500 (415-421) DOI:10.1038/nature12477) …

… on the basis of the different categories of mutational processes that underlie each signature.
Mechanistically, each mutational process comprises both a DNA damage component and a …

… the repertoire of mutational processes that contribute to the development of human cancer.
… signature is associated with each mutational process and provide an average reference …

… examination of mutational patterns in human cancer, summarizes … the concept of mutational
signatures and discusses their future … of signatures of mutational processes in human cancer. …

… mutational catalogue of a cancer genome harbors a mixture of signatures shaped by
different mutational processes… multiple base substitution patterns in human cancers [15, 22]. …

… on the repertoire of mutational processes contributing to the development of human
cancer including a comprehensive reference set of mutational signatures in human cancer. …

… nsNMF factorization revealed 21 mutational signatures. We found three APOBEC mutational
processes clearly segregating with the published APOBEC enzymology and trans-lesion …

… Moreover, by uniting the ML-derived mutational signatures with experimental data, … the
mutational processes that gave rise to these signatures and that caused the mutations in a cancer …