Long read sequencing platforms, which include the widely used Pacific Biosciences
(PacBio) platform and the emerging Oxford Nanopore platform, aim to produce sequence
fragments in excess of 15-20 kilobases, and have proved advantageous in the identification
of structural variants and easing genome assembly. However, long read sequencing
remains relatively expensive and error prone, and failed sequencing runs represent a
significant problem for genomics core facilities. To quantitatively assess the underlying …