Silk micrococoons for protein stabilisation and molecular encapsulation
U Shimanovich, FS Ruggeri, E De Genst… - Nature …, 2017 - nature.com
Naturally spun silks generate fibres with unique properties, including strength, elasticity and
biocompatibility. Here we describe a microfluidics-based strategy to spin liquid native silk,
obtained directly from the silk gland of Bombyx mori silkworms, into micron-scale capsules
with controllable geometry and variable levels of intermolecular β-sheet content in their
protein shells. We demonstrate that such micrococoons can store internally the otherwise
highly unstable liquid native silk for several months and without apparent effect on its …
biocompatibility. Here we describe a microfluidics-based strategy to spin liquid native silk,
obtained directly from the silk gland of Bombyx mori silkworms, into micron-scale capsules
with controllable geometry and variable levels of intermolecular β-sheet content in their
protein shells. We demonstrate that such micrococoons can store internally the otherwise
highly unstable liquid native silk for several months and without apparent effect on its …
Silk micrococoons for protein stabilisation and molecular encapsulation
F Vollrath, D Porter, U Shimanovich, S Ruggeri… - Nature …, 2017 - ora.ox.ac.uk
Naturally spun silks generate fibres with unique properties, including strength, elasticity and
biocompatibility. Here we describe a microfluidics-based strategy to spin liquid native silk,
obtained directly from the silk gland of Bombyx mori silkworms, into micron-scale capsules
with controllable geometry and variable levels of intermolecular b-sheet content in their
protein shells. We demonstrate that such micrococoons can store internally the otherwise
highly unstable liquid native silk for several months and without apparent effect on its …
biocompatibility. Here we describe a microfluidics-based strategy to spin liquid native silk,
obtained directly from the silk gland of Bombyx mori silkworms, into micron-scale capsules
with controllable geometry and variable levels of intermolecular b-sheet content in their
protein shells. We demonstrate that such micrococoons can store internally the otherwise
highly unstable liquid native silk for several months and without apparent effect on its …
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