The present communication describes a neurological disorder characterized by appearance of clinical symptoms like muscular weakness, unsteady gait, paresis of hind legs and lateral recumbency in two adult female cross-bred goats from a flock raised at the Lakhimpur College of Veterinary Science, North Lakhimpur, Assam. The affected goats with normal body temperature were unresponsive to initial heat therapy and neuro-stimulant administration. Subsequent blood examination by Knott’s technique revealed presence of sheathed microfilariae. Administration of diethyl carbamazine citrate (DEC)@ 100mg per os daily for 5 days and Tribivet-M@ 1.5 ml i/m every alternate day for 7 occasions led gradual resolution of clinical symptoms and complete recovery. Based on clinical observation, laboratory finding and response to treatment it was concluded that the two goats suffered from cerebrospinal nematodiasis, an unusual condition caused by erratic migration of the larval stage of Setaria digitata transmitted from its natural host cattle by mosquitoes. Detection of microfilariae in blood is also a rare finding.