Single‐limb irradiation induces local and systemic bone loss in a murine model
Increased fracture risk is commonly reported in cancer patients receiving radiotherapy,
particularly at sites within the field of treatment. The direct and systemic effects of ionizing
radiation on bone at a therapeutic dose are not well‐characterized in clinically relevant
animal models. Using 20‐week‐old male C57Bl/6 mice, effects of irradiation (right hindlimb;
2 Gy) on bone volume and microarchitecture were evaluated prospectively by
microcomputed tomography and histomorphometry and compared to contralateral‐shielded …
particularly at sites within the field of treatment. The direct and systemic effects of ionizing
radiation on bone at a therapeutic dose are not well‐characterized in clinically relevant
animal models. Using 20‐week‐old male C57Bl/6 mice, effects of irradiation (right hindlimb;
2 Gy) on bone volume and microarchitecture were evaluated prospectively by
microcomputed tomography and histomorphometry and compared to contralateral‐shielded …
[PDF][PDF] Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model
MD Mohammad, TA Guise - academia.edu
Increased fracture risk is commonly reported in cancer patients receiving radiotherapy,
particularly at sites within the field of treatment. The direct and systemic effects of ionizing
radiation on bone at a therapeutic dose are not well characterized in clinically relevant
animal models. Using twenty-week male C57Bl/6 mice, effects of irradiation (right hindlimb;
2 Gy) on bone volume and microarchitecture were evaluated prospectively by
microcomputed tomography and histomorphometry and compared to contralateral-shielded …
particularly at sites within the field of treatment. The direct and systemic effects of ionizing
radiation on bone at a therapeutic dose are not well characterized in clinically relevant
animal models. Using twenty-week male C57Bl/6 mice, effects of irradiation (right hindlimb;
2 Gy) on bone volume and microarchitecture were evaluated prospectively by
microcomputed tomography and histomorphometry and compared to contralateral-shielded …
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