Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast
V Geldhof, LPMH de Rooij, L Sokol… - Nature …, 2022 - nature.com
Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is
lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs)
from 9 BC patients and compare them to published EC taxonomies from lung tumors.
Angiogenic ECs are phenotypically similar, while other EC subtypes are different. Predictive
interactome analysis reveals known but also previously unreported receptor-ligand
interactions between ECs and immune cells, suggesting an involvement of breast EC …
lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs)
from 9 BC patients and compare them to published EC taxonomies from lung tumors.
Angiogenic ECs are phenotypically similar, while other EC subtypes are different. Predictive
interactome analysis reveals known but also previously unreported receptor-ligand
interactions between ECs and immune cells, suggesting an involvement of breast EC …
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